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Speaker: Ryan Webler, MD

Autonomic hyperactivation is a core feature of anxiety-related disorders that is inadequately addressed by current treatment approaches. Localizing autonomic
arousal to a specific brain circuit could inform the development of new treatments.

Here, Dr. Webler presents causal circuit mapping findings showing that focal brain stimulation sites that rapidly modify autonomic arousal map to a convergent brain circuit across stimulation modalities (TMS, DBS, LIFU). In additional independent datasets, modulation of this circuit predicts sustained changes in anxiety-related autonomic hyperactivation. These findings: (1) implicate the autonomic arousal circuit as a potential brain stimulation target for autonomic hyperactivation, and (2) suggest that rapid autonomic arousal changes could potentially serve as a biomarker of sustained autonomic arousal changes.

Key learning objectives include:

• Describe how autonomic hyperactivation to anxiogenic stimuli contributes to clinical anxiety, and why it is inadequately addressed by current treatments.
• Explain how focal brain stimulation (e.g., TMS, DBS, LIFU) can rapidly modulate autonomic outflow, and how this outflow maps onto a convergent brain circuit for sympathetic arousal.
• Evaluate the evidence that the autonomic arousal circuit predicts sustained changes in anxious arousal and identify its potential as a therapeutic target.

One CME credit is available.  CE Language

Take advantage of our live Q&A session at the conclusion of the webinar.

*Registered attendees will receive access to the on-demand video recording by Friday, August 7, 2026. You will receive an email notification with instructions on accessing the video. You may register for the on-demand webinar any time after the live webinar.

When:

USA - August 4, 2026 at 8:00pm ET | 5:00pm PT
UK- August 5, 2026 at 1:00am BST
Australia- August 5, 2026 at 10:00am AEST

Cost:

Member: $25
Trainee Member: FREE
Non-Member: $50

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About the Speaker

Ryan Webler, MD

Dr. Ryan Webler is a postdoctoral research fellow at Harvard Medical School where he uses causal circuit mapping to develop better brain stimulation treatments for anxiety-related disorders. Complementing his research agenda, he is also a postdoctoral clinical fellow at Boston Precision Neurotherapeutics where he implements evidence-based psychotherapeutic protocols to bolster TMS gains.