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Speaker: Alex McGirr, MD, PhD, FRCPC

Transcranial magnetic stimulation is delivered in patterns of pulses that are informed by pre-clinical electrophysiology to induce changes at the level of the synapse. Our delivery of this treatment is agnostic to two major confounds that influence the ability of synaptic weights to change in response to stimulation:
a) disease processes limiting plasticity
b) concurrent pharmacology
This grand rounds will review clinically relevant implications of these, and the emerging space using pharmacological adjuvants to enhance the effects of stimulation and its relation to clinical outcomes.

Key learning objectives include:

• Explain the mechanisms of transcranial magnetic stimulation (TMS), inclucing how pulse patterns influence synaptic plasticity and the role of electrophysiological principles.
• Identify factors that affect synaptic responsiveness to TMS, such as disease-related limitations in plasticity and the impact of concurrent pharmacological treatments.
• Discuss the clinical implications of combining TMS with pharmacological adjuvants, including how these interactions can enhance stimulation effects and influence clinical outcomes.

Take advantage of our live Q&A session at the conclusion of the webinar.

*Registered attendees will receive access to the on-demand video recording by Friday, December 5, 2025. You will receive an email notification with instructions on accessing the video. You may register for the on-demand webinar any time after the live webinar.

When:

USA - December 2, 2025 at 8:00pm ET | 5:00pm PT
UK- December 3, 2025 at 1:00am GMT
Australia- December 3, 2025 at 12:00pm AEDT

Cost:

Member: $25
Trainee Member: FREE
Non-Member: $50

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About the Speaker

Alexander McGirr, MD, PhD, FRCPC
Dr. Alexander McGirr is a psychiatrist and clinician scientist at the University of Calgary, Canada. He trained across major Canadian institutions, including
McGill University (undergraduate and masters of neuroscience), the University of Toronto (MD), and the University of British Columbia (psychiatry residency
and PhD neuroscience). His clinical work and research focuses on mood disorders, circuit dissection, and non-invasive neurostimulation as both a means
of probing the brain and inducing changes in neural circuits underlying pathology. Although his research program includes both basic science and
clinical arms, the focus of this ground rounds will be clinical.